Cargando…

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

Mitophagy, the selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis. Mutations of proteins in the pathway cause neurodegenerative diseases, suggesting defective mitochondrial turnover contributes to neurodegeneration. In primary rat hippocampal neuron...

Descripción completa

Detalles Bibliográficos
Autores principales: Evans, Chantell S, Holzbaur, Erika LF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959996/
https://www.ncbi.nlm.nih.gov/pubmed/31934852
http://dx.doi.org/10.7554/eLife.50260