High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-MHC, i.e., the TCR binding avidity. A current challenge in onco-immunology lies in the evaluation of vaccine protocols selecting for tumor-specific T-cells of highest avidity, offering maximal immune protection...

Descripción completa

Detalles Bibliográficos
Autores principales: Carretero-Iglesia, Laura, Couturaud, Barbara, Baumgaertner, Petra, Schmidt, Julien, Maby-El Hajjami, Hélène, Speiser, Daniel E., Hebeisen, Michael, Rufer, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960191/
https://www.ncbi.nlm.nih.gov/pubmed/31969886
http://dx.doi.org/10.3389/fimmu.2019.03016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960191/
https://www.ncbi.nlm.nih.gov/pubmed/31969886
http://dx.doi.org/10.3389/fimmu.2019.03016

Ejemplares similares