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High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-MHC, i.e., the TCR binding avidity. A current challenge in onco-immunology lies in the evaluation of vaccine protocols selecting for tumor-specific T-cells of highest avidity, offering maximal immune protection...

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Detalles Bibliográficos
Autores principales:	Carretero-Iglesia, Laura, Couturaud, Barbara, Baumgaertner, Petra, Schmidt, Julien, Maby-El Hajjami, Hélène, Speiser, Daniel E., Hebeisen, Michael, Rufer, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960191/ https://www.ncbi.nlm.nih.gov/pubmed/31969886 http://dx.doi.org/10.3389/fimmu.2019.03016

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