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Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis

Background: In the human central nervous system (CN), resting astrocytes do not visually show endothelin-1 (ET-1)-like immunoreactivity. In patients with multiple sclerosis (MS), an inflammatory disorder of the CNS, high levels of ET-1 are found in reactive astrocytes in demyelinated plaques. ET-1 m...

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Detalles Bibliográficos
Autores principales: Hostenbach, Stéphanie, D’Haeseleer, Miguel, Kooijman, Ron, De Keyser, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960227/
https://www.ncbi.nlm.nih.gov/pubmed/31969819
http://dx.doi.org/10.3389/fphar.2019.01491