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Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s

Myosin 1s have critical roles in linking membranes to the actin cytoskeleton via direct binding to acidic lipids. Lipid binding may occur through PIP3/PIP2-specific PH domains or nonspecific ionic interactions involving basic-hydrophobic (BH) sites but the mechanism of myosin 1s distinctive lipid ta...

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Detalles Bibliográficos
Autores principales: Brzeska, Hanna, Gonzalez, Jesus, Korn, Edward D., Titus, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960411/
https://www.ncbi.nlm.nih.gov/pubmed/31774725
http://dx.doi.org/10.1091/mbc.E19-08-0475