PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

Although adoptive T‐cell therapy has shown remarkable clinical efficacy in haematological malignancies, its success in combating solid tumours has been limited. Here, we report that PTPN2 deletion in T cells enhances cancer immunosurveillance and the efficacy of adoptively transferred tumour‐specifi...

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Detalles Bibliográficos
Autores principales: Wiede, Florian, Lu, Kun‐Hui, Du, Xin, Liang, Shuwei, Hochheiser, Katharina, Dodd, Garron T, Goh, Pei K, Kearney, Conor, Meyran, Deborah, Beavis, Paul A, Henderson, Melissa A, Park, Simone L, Waithman, Jason, Zhang, Sheng, Zhang, Zhong‐Yin, Oliaro, Jane, Gebhardt, Thomas, Darcy, Phillip K, Tiganis, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960448/
https://www.ncbi.nlm.nih.gov/pubmed/31803974
http://dx.doi.org/10.15252/embj.2019103637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960448/
https://www.ncbi.nlm.nih.gov/pubmed/31803974
http://dx.doi.org/10.15252/embj.2019103637

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