Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

The carboxylesterase Notum is a key negative regulator of the Wnt signaling pathway by mediating the depalmitoleoylation of Wnt proteins. Our objective was to discover potent small molecule inhibitors of Notum suitable for exploring the regulation of Wnt signaling in the central nervous system. Scaf...

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Detalles Bibliográficos
Autores principales: Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961116/
https://www.ncbi.nlm.nih.gov/pubmed/31862412
http://dx.doi.org/10.1016/j.bmcl.2019.126751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961116/
https://www.ncbi.nlm.nih.gov/pubmed/31862412
http://dx.doi.org/10.1016/j.bmcl.2019.126751

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