Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway

The search for novel targeted inhibitors active on glioblastoma multiforme is crucial to develop new treatments for this unmet clinical need. Herein, we report the results from a screening campaign against glioma cell lines using a proprietary library of 100 structurally-related pyrazolopyrimidines....

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Detalles Bibliográficos
Autores principales: Valero, Teresa, Baillache, Daniel J., Fraser, Craig, Myers, Samuel H., Unciti-Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961122/
https://www.ncbi.nlm.nih.gov/pubmed/31787462
http://dx.doi.org/10.1016/j.bmc.2019.115215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961122/
https://www.ncbi.nlm.nih.gov/pubmed/31787462
http://dx.doi.org/10.1016/j.bmc.2019.115215

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