Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts

DNA in dividing cells is prone to mutagenesis, with mutations making key contributions to human disease including cancer. The tumour suppressor gene TP53 is the most frequently mutated gene in human tumours. Here, we present a robust protocol for studying TP53 mutagenesis utilising human TP53 knock-...

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Detalles Bibliográficos
Autores principales: Hölzl-Armstrong, Lisa, Kucab, Jill E., Korenjak, Michael, Luijten, Mirjam, Phillips, David H., Zavadil, Jiri, Arlt, Volker M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961128/
https://www.ncbi.nlm.nih.gov/pubmed/31766274
http://dx.doi.org/10.3390/mps2040085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961128/
https://www.ncbi.nlm.nih.gov/pubmed/31766274
http://dx.doi.org/10.3390/mps2040085

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