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Disease related single point mutations alter the global dynamics of a tetratricopeptide (TPR) α-solenoid domain
Tetratricopeptide repeat (TPR) proteins belong to the class of α-solenoid proteins, in which repetitive units of α-helical hairpin motifs stack to form superhelical, often highly flexible structures. TPR domains occur in a wide variety of proteins, and perform key functional roles including protein...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961204/ https://www.ncbi.nlm.nih.gov/pubmed/31628985 http://dx.doi.org/10.1016/j.jsb.2019.107405 |