Bayesian group sequential designs for phase III emergency medicine trials: a case study using the PARAMEDIC2 trial

BACKGROUND: Phase III trials often require large sample sizes, leading to high costs and delays in clinical decision-making. Group sequential designs can improve trial efficiency by allowing for early stopping for efficacy and/or futility and thus may decrease the sample size, trial duration and ass...

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Detalles Bibliográficos
Autores principales: Ryan, Elizabeth G., Stallard, Nigel, Lall, Ranjit, Ji, Chen, Perkins, Gavin D., Gates, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961266/
https://www.ncbi.nlm.nih.gov/pubmed/31937351
http://dx.doi.org/10.1186/s13063-019-4024-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961266/
https://www.ncbi.nlm.nih.gov/pubmed/31937351
http://dx.doi.org/10.1186/s13063-019-4024-x

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