The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme design

We develop an L-platform/L-scaffold framework we hypothesize may serve as a blueprint to facilitate site-specific RNA-cleaving nucleic acid enzyme design. Building on the L-platform motif originally described by Suslov and coworkers, we identify new critical scaffolding elements required to anchor a...

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Detalles Bibliográficos
Autores principales: Gaines, Colin S., Piccirilli, Joseph A., York, Darrin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961537/
https://www.ncbi.nlm.nih.gov/pubmed/31776179
http://dx.doi.org/10.1261/rna.071894.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961537/
https://www.ncbi.nlm.nih.gov/pubmed/31776179
http://dx.doi.org/10.1261/rna.071894.119

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