Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer

Nucleosomes inhibit excision repair of DNA damage caused by ultraviolet (UV) light, and it has been generally assumed that repair inhibition is equivalent on both sides of the nucleosome dyad. Here, we use genome-wide repair data to show that repair of UV damage in nucleosomes is asymmetric. In yeas...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Peng, Smerdon, Michael J., Roberts, Steven A., Wyrick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961582/
https://www.ncbi.nlm.nih.gov/pubmed/31871068
http://dx.doi.org/10.1101/gr.253146.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961582/
https://www.ncbi.nlm.nih.gov/pubmed/31871068
http://dx.doi.org/10.1101/gr.253146.119

Ejemplares similares