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Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer
Deciphering principles of inter-tumoral heterogeneity is crucial for refinement of precision oncology. We have recently demonstrated that ‘oncogenic cooperation‘ between somatic mutations and regulatory germline variants can serve as a major cause for inter-tumoral heterogeneity, suggesting the requ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961672/ https://www.ncbi.nlm.nih.gov/pubmed/31993496 http://dx.doi.org/10.1080/23723556.2019.1682924 |