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Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce mol...

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Detalles Bibliográficos
Autores principales: Emdal, Kristina B., Lundby, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961691/
https://www.ncbi.nlm.nih.gov/pubmed/31993501
http://dx.doi.org/10.1080/23723556.2019.1692643