Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce mol...

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Detalles Bibliográficos
Autores principales: Emdal, Kristina B., Lundby, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961691/
https://www.ncbi.nlm.nih.gov/pubmed/31993501
http://dx.doi.org/10.1080/23723556.2019.1692643
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author Emdal, Kristina B.
Lundby, Alicia
author_facet Emdal, Kristina B.
Lundby, Alicia
author_sort Emdal, Kristina B.
collection PubMed
description We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.
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spelling pubmed-69616912020-09-28 Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues Emdal, Kristina B. Lundby, Alicia Mol Cell Oncol Commentary We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation. Taylor & Francis 2019-12-06 /pmc/articles/PMC6961691/ /pubmed/31993501 http://dx.doi.org/10.1080/23723556.2019.1692643 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Emdal, Kristina B.
Lundby, Alicia
Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
title Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
title_full Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
title_fullStr Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
title_full_unstemmed Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
title_short Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
title_sort molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961691/
https://www.ncbi.nlm.nih.gov/pubmed/31993501
http://dx.doi.org/10.1080/23723556.2019.1692643
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