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Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues
We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce mol...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961691/ https://www.ncbi.nlm.nih.gov/pubmed/31993501 http://dx.doi.org/10.1080/23723556.2019.1692643 |