Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury

OBJECTIVES: Cerebral ischemia/reperfusion (IR) drives oxidative stress and injurious metabolic processes that lead to redox imbalance, inflammation, and tissue damage. However, the key mediators of reperfusion injury remain unclear, and therefore, there is considerable interest in therapeutically ta...

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Detalles Bibliográficos
Autores principales: Cordes, Thekla, Lucas, Alfredo, Divakaruni, Ajit S., Murphy, Anne N., Cabrales, Pedro, Metallo, Christian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961711/
https://www.ncbi.nlm.nih.gov/pubmed/32029222
http://dx.doi.org/10.1016/j.molmet.2019.11.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961711/
https://www.ncbi.nlm.nih.gov/pubmed/32029222
http://dx.doi.org/10.1016/j.molmet.2019.11.019

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