Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

Abundant APOBEC3 (A3) deaminase-mediated mutations can dominate the mutational landscape (‘mutator phenotype’) of some cancers, however, the basis of this sporadic vulnerability is unknown. We show here that elevated expression of the bifunctional DNA glycosylase, NEIL2, sensitizes breast cancer cel...

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Detalles Bibliográficos
Autores principales: Shen, Birong, Chapman, Joseph H, Custance, Michael F, Tricola, Gianna M, Jones, Charles E, Furano, Anthony V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961979/
https://www.ncbi.nlm.nih.gov/pubmed/31904337
http://dx.doi.org/10.7554/eLife.51605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961979/
https://www.ncbi.nlm.nih.gov/pubmed/31904337
http://dx.doi.org/10.7554/eLife.51605

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