The Epstein–Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization

Epstein–Barr virus (EBV) immortalizes human B-lymphocytes and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA dama...

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Detalles Bibliográficos
Autores principales: Wang, Jiayu, Nagy, Noemi, Masucci, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962091/
https://www.ncbi.nlm.nih.gov/pubmed/31511648
http://dx.doi.org/10.1038/s41388-019-1003-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962091/
https://www.ncbi.nlm.nih.gov/pubmed/31511648
http://dx.doi.org/10.1038/s41388-019-1003-3

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