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Role of innate lymphoid cells in chronic colitis during anti-IL-17A therapy

IL-17A is an important cytokine in intestinal inflammation. However, anti-IL-17A therapy does not improve clinical outcomes in patients with Crohn’s disease. We aimed to evaluate the role of RORγt(+) innate lymphoid cells (ILCs) in murine colitis models in the absence of IL-17A. An acute colitis mod...

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Detalles Bibliográficos
Autores principales: Park, Chan Hyuk, Lee, A-reum, Ahn, Sang Bong, Eun, Chang Soo, Han, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962146/
https://www.ncbi.nlm.nih.gov/pubmed/31941937
http://dx.doi.org/10.1038/s41598-019-57233-w