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A continuous evolution system for contracting the host range of bacteriophage T7

Bacteriophage T7 is an intracellular parasite that recognizes its host via its tail and tail fiber proteins, known as receptor-binding proteins (RBPs). The RBPs attach to specific lipopolysaccharide (LPS) features on the host. Various studies have shown expansion of the phage’s host range via mutati...

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Detalles Bibliográficos
Autores principales: Holtzman, Tzvi, Globus, Rea, Molshanski-Mor, Shahar, Ben-Shem, Adam, Yosef, Ido, Qimron, Udi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962156/
https://www.ncbi.nlm.nih.gov/pubmed/31941920
http://dx.doi.org/10.1038/s41598-019-57221-0