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Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles

Lecithin:cholesterol acyltransferase (LCAT) catalyzes a critical step of reverse cholesterol transport by esterifying cholesterol in high density lipoprotein (HDL) particles. LCAT is activated by apolipoprotein A-I (ApoA-I), which forms a double belt around HDL, however the manner in which LCAT enga...

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Detalles Bibliográficos
Autores principales: Manthei, Kelly A., Patra, Dhabaleswar, Wilson, Christopher J., Fawaz, Maria V., Piersimoni, Lolita, Shenkar, Jenny Capua, Yuan, Wenmin, Andrews, Philip C., Engen, John R., Schwendeman, Anna, Ohi, Melanie D., Tesmer, John J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962161/
https://www.ncbi.nlm.nih.gov/pubmed/31942029
http://dx.doi.org/10.1038/s42003-019-0749-z