Cargando…

Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles

Lecithin:cholesterol acyltransferase (LCAT) catalyzes a critical step of reverse cholesterol transport by esterifying cholesterol in high density lipoprotein (HDL) particles. LCAT is activated by apolipoprotein A-I (ApoA-I), which forms a double belt around HDL, however the manner in which LCAT enga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manthei, Kelly A., Patra, Dhabaleswar, Wilson, Christopher J., Fawaz, Maria V., Piersimoni, Lolita, Shenkar, Jenny Capua, Yuan, Wenmin, Andrews, Philip C., Engen, John R., Schwendeman, Anna, Ohi, Melanie D., Tesmer, John J. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962161/ https://www.ncbi.nlm.nih.gov/pubmed/31942029 http://dx.doi.org/10.1038/s42003-019-0749-z

Ejemplares similares

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
por: Manthei, Kelly A, et al.
Publicado: (2018)

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase
por: Glukhova, Alisa, et al.
Publicado: (2015)

Lecithin:cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings
por: Norum, Kaare R., et al.
Publicado: (2020)

Interaction of lecithin:cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I-derived peptides
por: Casteleijn, Marco G., et al.
Publicado: (2018)

A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency
por: Vitali, Cecilia, et al.
Publicado: (2022)

Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency
por: Fistrek Prlic, Margareta, et al.
Publicado: (2022)

The HDL mimetic CER‐001 remodels plasma lipoproteins and reduces kidney lipid deposits in inherited lecithin:cholesterol acyltransferase deficiency
por: Pavanello, Chiara, et al.
Publicado: (2021)

Two novel mutations of lecithin:cholesterol acyltransferase (LCAT) gene and the influence of APOE genotypes on clinical manifestations
por: Katayama, Akihiro, et al.
Publicado: (2011)

Beta2-adrenergic activity modulates vascular tone regulation in lecithin:cholesterol acyltransferase knockout mice
por: Manzini, S., et al.
Publicado: (2015)

Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia
por: Conca, Paola, et al.
Publicado: (2012)

High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
por: Ossoli, Alice, et al.
Publicado: (2016)

Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism
por: Gunawardane, Ruwanthi N., et al.
Publicado: (2016)

LCAT-trial-24 weeks: Protocol for a clinical study to evaluate the safety of regenerative medicine and gene therapy by the autologous transplantation of human lecithin:cholesterol acyltransferase gene-transduced human pre-adipocytes
por: Kuroda, Masayuki, et al.
Publicado: (2022)

Corneal thickness in the case of familial lecithin-cholesterol acyltransferase deficiency
por: Kinoshita, Shinsuke, et al.
Publicado: (2021)

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2018)

MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport
por: George, Richard T., et al.
Publicado: (2021)

Two Cases of Acquired High-Density Lipoprotein Deficiency with Immunoglobulin G4-Related Lecithin–Cholesterol Acyltransferase Autoantibody
por: Komatsu, Tomohiro, et al.
Publicado: (2023)

Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria
por: Althaf, Mohammed Mahdi, et al.
Publicado: (2015)

Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk: a longitudinal pilot study
por: Yokoyama, Katsuaki, et al.
Publicado: (2018)

Lecithin: Cholesterol Acyltransferase and Na(+)-K(+)-ATPase Activity in Patients with Breast Cancer
por: Özmen, Hilal Kiziltunç, et al.
Publicado: (2013)

Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease
por: Baragetti, Andrea, et al.
Publicado: (2020)

Association of Lecithin Cholesterol Acyltransferase rs5923 Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study
por: Naseri, Mohsen, et al.
Publicado: (2015)

Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia
por: Tobar, Hugo E., et al.
Publicado: (2019)

Familial lecithin-cholesterol acyltransferase deficiency: If so rare, why so frequent in the state of Piauí, northeastern Brazil?
por: de Serpa Brandão, Rafael Melo Santos, et al.
Publicado: (2022)

Plasma Lecithin-Cholesterol Acyltransferase Activity in Pregnant Women Enrolled in the iLiNS-DYAD Trial in Ghana
por: Hong, Brian, et al.
Publicado: (2022)

Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis
por: Gao, Hongliang, et al.
Publicado: (2022)

Effect of Lecithin-Bound Iodine Treatment on Inherited Retinal Degeneration in Mice
por: Kohno, Hideo, et al.
Publicado: (2021)

Crystal structure of a membrane-bound O-acyltransferase
por: Ma, Dan, et al.
Publicado: (2018)

Corrigendum: Influence of lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: A 45 years bibliometrics analysis
por: Gao, Hongliang, et al.
Publicado: (2023)

Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids
por: Giorgi, Laura, et al.
Publicado: (2022)

Interleukin-1 as an Injury Signal Mobilizes Retinyl Esters in Hepatic Stellate Cells through Down Regulation of Lecithin Retinol Acyltransferase
por: Kida, Yujiro, et al.
Publicado: (2011)

Cross-linking/mass spectrometry at the crossroads
por: Piersimoni, Lolita, et al.
Publicado: (2020)

Positive allosteric modulators of lecithin: Cholesterol acyltransferase adjust the orientation of the membrane-binding domain and alter its spatial free energy profile
por: Niemelä, Akseli, et al.
Publicado: (2021)

Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N-acyltransferase
por: Smithers, Luke, et al.
Publicado: (2023)

IMMUNIZATION EXPERIMENTS WITH LECITHIN
por: Levene, P. A., et al.
Publicado: (1927)

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis
por: Wiktor, Maciej, et al.
Publicado: (2017)

Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress
por: Sugimoto, Masahiko, et al.
Publicado: (2016)

Low Density Lipoprotein - important player in increasing cryoprotective efficiency of soybean lecithin-based bull semen extenders
por: Ondřej, Šimoník, et al.
Publicado: (2019)

Overexpression of the rice BAHD acyltransferase AT10 increases xylan-bound p-coumarate and reduces lignin in Sorghum bicolor
por: Tian, Yang, et al.
Publicado: (2021)

Lecithin in Neurasthenia, and in Graves' Disease
Publicado: (1909)

Cannot write session to /tmp/vufind_sessions/sess_gs9rv0d488tl0o3o5qb5sk22ju