Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

Chimeric antigen receptor (CAR)-expressing T cells targeting B-cell maturation antigen (BCMA) have activity against multiple myeloma, but improvements in anti-BCMA CARs are needed. We demonstrated recipient anti-CAR T-cell responses against a murine single-chain variable fragment (scFv) used clinica...

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Detalles Bibliográficos
Autores principales: Lam, Norris, Trinklein, Nathan D., Buelow, Benjamin, Patterson, George H., Ojha, Namrata, Kochenderfer, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962219/
https://www.ncbi.nlm.nih.gov/pubmed/31941907
http://dx.doi.org/10.1038/s41467-019-14119-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962219/
https://www.ncbi.nlm.nih.gov/pubmed/31941907
http://dx.doi.org/10.1038/s41467-019-14119-9

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