Targeting the tumor vasculature with engineered cystine-knot miniproteins

The extra domain B splice variant (EDB) of human fibronectin selectively expressed in the tumor vasculature is an attractive target for cancer imaging and therapy. Here, we describe the generation and characterization of EDB-specific optical imaging probes. By screening combinatorial cystine-knot mi...

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Detalles Bibliográficos
Autores principales: Lui, Bonny Gaby, Salomon, Nadja, Wüstehube-Lausch, Joycelyn, Daneschdar, Matin, Schmoldt, Hans-Ulrich, Türeci, Özlem, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962393/
https://www.ncbi.nlm.nih.gov/pubmed/31941901
http://dx.doi.org/10.1038/s41467-019-13948-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962393/
https://www.ncbi.nlm.nih.gov/pubmed/31941901
http://dx.doi.org/10.1038/s41467-019-13948-y

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