Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G(1) monoclonal antibody lost more than half of its ADCC activity after heat stress at 40 °C for 4 months. Size-exclusion and ion-exchange chrom...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Xiaojun, Machiesky, Lee Ann, De Mel, Niluka, Du, Qun, Xu, Weichen, Washabaugh, Michael, Jiang, Xu-Rong, Wang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962426/
https://www.ncbi.nlm.nih.gov/pubmed/31941950
http://dx.doi.org/10.1038/s41598-019-57184-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962426/
https://www.ncbi.nlm.nih.gov/pubmed/31941950
http://dx.doi.org/10.1038/s41598-019-57184-2

Ejemplares similares