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Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G(1) monoclonal antibody lost more than half of its ADCC activity after heat stress at 40 °C for 4 months. Size-exclusion and ion-exchange chrom...

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Detalles Bibliográficos
Autores principales:	Lu, Xiaojun, Machiesky, Lee Ann, De Mel, Niluka, Du, Qun, Xu, Weichen, Washabaugh, Michael, Jiang, Xu-Rong, Wang, Jihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962426/ https://www.ncbi.nlm.nih.gov/pubmed/31941950 http://dx.doi.org/10.1038/s41598-019-57184-2

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