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Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation

The sodium-chloride cotransporter (NCC) in the distal convoluted tubule contributes importantly to sodium balance and blood pressure (BP) regulation. NCC phosphorylation determines transport activity and has a diurnal rhythm influenced by glucocorticoids. Disturbing this rhythm induces “nondipping”...

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Detalles Bibliográficos
Autores principales: Ivy, Jessica Ruth, Jones, Natalie K., Costello, Hannah M., Mansley, Morag K., Peltz, Theresa S., Flatman, Peter W., Bailey, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962506/
https://www.ncbi.nlm.nih.gov/pubmed/31588796
http://dx.doi.org/10.1152/ajprenal.00372.2019