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Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation
The sodium-chloride cotransporter (NCC) in the distal convoluted tubule contributes importantly to sodium balance and blood pressure (BP) regulation. NCC phosphorylation determines transport activity and has a diurnal rhythm influenced by glucocorticoids. Disturbing this rhythm induces “nondipping”...
Autores principales: | Ivy, Jessica Ruth, Jones, Natalie K., Costello, Hannah M., Mansley, Morag K., Peltz, Theresa S., Flatman, Peter W., Bailey, Matthew A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Physiological Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962506/ https://www.ncbi.nlm.nih.gov/pubmed/31588796 http://dx.doi.org/10.1152/ajprenal.00372.2019 |
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