Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists

Background: Epidermal growth factor receptor (EGFR) inhibitors can cause serious cutaneous toxicities, including pruritus and papulopustular acneiform skin eruptions. Increasingly, the neurokinin-1 receptor (NK1R) antagonist aprepitant is being utilized as an anti-pruritic agent in the treatment of...

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Detalles Bibliográficos
Autores principales: Kwatra, Shawn G., Boozalis, Emily, Huang, Amy H., Nanni, Cory, Khanna, Raveena, Williams, Kyle A., Semenov, Yevgeniy R., Roberts, Callie M., Burns, Robert F., Krischak, Madison, Kwatra, Madan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963385/
https://www.ncbi.nlm.nih.gov/pubmed/31835310
http://dx.doi.org/10.3390/medicines6040114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963385/
https://www.ncbi.nlm.nih.gov/pubmed/31835310
http://dx.doi.org/10.3390/medicines6040114

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