Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins

Ebola virus (EBOV) infection can cause severe and frequently fatal disease in human patients. The EBOV glycoprotein (GP) mediates viral entry into host cells. For this, GP depends on priming by the pH-dependent endolysosomal cysteine proteases cathepsin B (CatB) and, to a lesser degree, cathepsin L...

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Detalles Bibliográficos
Autores principales: Hoffmann, Markus, Kaufmann, Svenja Victoria, Fischer, Carina, Maurer, Wiebke, Moldenhauer, Anna-Sophie, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963435/
https://www.ncbi.nlm.nih.gov/pubmed/31618932
http://dx.doi.org/10.3390/pathogens8040192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963435/
https://www.ncbi.nlm.nih.gov/pubmed/31618932
http://dx.doi.org/10.3390/pathogens8040192

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