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Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens
Two experimental models were conducted to evaluate and compare the effect of ascorbic acid (AA) or curcumin formulated in a solid dispersion (SD-CUR) as prophylactic or therapeutic alternatives to prevent or control S. Enteritidis (SE) infection in broiler chickens. In the prophylactic model, dietar...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963554/ https://www.ncbi.nlm.nih.gov/pubmed/31717681 http://dx.doi.org/10.3390/pathogens8040229 |
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author | Hernandez-Patlan, Daniel Solis-Cruz, Bruno Pontin, Karine P. Latorre, Juan D. Hernandez-Velasco, Xochitl Merino-Guzman, Ruben Mendez-Albores, Abraham Hargis, Billy M. Lopez-Arellano, Raquel Tellez-Isaias, Guillermo |
author_facet | Hernandez-Patlan, Daniel Solis-Cruz, Bruno Pontin, Karine P. Latorre, Juan D. Hernandez-Velasco, Xochitl Merino-Guzman, Ruben Mendez-Albores, Abraham Hargis, Billy M. Lopez-Arellano, Raquel Tellez-Isaias, Guillermo |
author_sort | Hernandez-Patlan, Daniel |
collection | PubMed |
description | Two experimental models were conducted to evaluate and compare the effect of ascorbic acid (AA) or curcumin formulated in a solid dispersion (SD-CUR) as prophylactic or therapeutic alternatives to prevent or control S. Enteritidis (SE) infection in broiler chickens. In the prophylactic model, dietary administration of AA showed a significant reduction in SE counts in crop compared to the positive control (PC) group (p < 0.05), whereas in cecal tonsils (CT), SD-CUR significantly reduced SE recovery. Superoxide dismutase (SOD) activity was significantly higher in chickens supplemented with AA or SD-CUR, and total intestinal IgA levels were significantly lower in both treatments when compared to the PC group. Serum fluorescein isothiocyanate-dextran (FITC-d) levels were reduced by SD-CUR compared to PC, while AA presented significantly lower total aerobic bacteria. In the therapeutic model, only the dietary administration of AA significantly decreased SE in crop and CT on days 3 and 10 post-challenge. FITC-d levels were significantly lower in both treated groups in comparison to PC, but IgA levels were significantly reduced only by AA. The results suggest that dietary AA and SD-CUR have different modes of action to reduce SE intestinal colonization in two different challenge models in broiler chickens. |
format | Online Article Text |
id | pubmed-6963554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69635542020-01-30 Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens Hernandez-Patlan, Daniel Solis-Cruz, Bruno Pontin, Karine P. Latorre, Juan D. Hernandez-Velasco, Xochitl Merino-Guzman, Ruben Mendez-Albores, Abraham Hargis, Billy M. Lopez-Arellano, Raquel Tellez-Isaias, Guillermo Pathogens Article Two experimental models were conducted to evaluate and compare the effect of ascorbic acid (AA) or curcumin formulated in a solid dispersion (SD-CUR) as prophylactic or therapeutic alternatives to prevent or control S. Enteritidis (SE) infection in broiler chickens. In the prophylactic model, dietary administration of AA showed a significant reduction in SE counts in crop compared to the positive control (PC) group (p < 0.05), whereas in cecal tonsils (CT), SD-CUR significantly reduced SE recovery. Superoxide dismutase (SOD) activity was significantly higher in chickens supplemented with AA or SD-CUR, and total intestinal IgA levels were significantly lower in both treatments when compared to the PC group. Serum fluorescein isothiocyanate-dextran (FITC-d) levels were reduced by SD-CUR compared to PC, while AA presented significantly lower total aerobic bacteria. In the therapeutic model, only the dietary administration of AA significantly decreased SE in crop and CT on days 3 and 10 post-challenge. FITC-d levels were significantly lower in both treated groups in comparison to PC, but IgA levels were significantly reduced only by AA. The results suggest that dietary AA and SD-CUR have different modes of action to reduce SE intestinal colonization in two different challenge models in broiler chickens. MDPI 2019-11-10 /pmc/articles/PMC6963554/ /pubmed/31717681 http://dx.doi.org/10.3390/pathogens8040229 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hernandez-Patlan, Daniel Solis-Cruz, Bruno Pontin, Karine P. Latorre, Juan D. Hernandez-Velasco, Xochitl Merino-Guzman, Ruben Mendez-Albores, Abraham Hargis, Billy M. Lopez-Arellano, Raquel Tellez-Isaias, Guillermo Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens |
title | Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens |
title_full | Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens |
title_fullStr | Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens |
title_full_unstemmed | Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens |
title_short | Evaluation of Ascorbic Acid or Curcumin Formulated in a Solid Dispersion on Salmonella Enteritidis Infection and Intestinal Integrity in Broiler Chickens |
title_sort | evaluation of ascorbic acid or curcumin formulated in a solid dispersion on salmonella enteritidis infection and intestinal integrity in broiler chickens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963554/ https://www.ncbi.nlm.nih.gov/pubmed/31717681 http://dx.doi.org/10.3390/pathogens8040229 |
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