Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug. One of the most studied enzyme–prodrug combinations is the nitroreductase from Escherichia coli (NfnB) with the prodru...

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Detalles Bibliográficos
Autores principales: Anderson, Simon D., Hobbs, Robert J., Gwenin, Vanessa V., Ball, Patrick, Bennie, Lindsey A., Coulter, Jonathan A., Gwenin, Chris D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963571/
https://www.ncbi.nlm.nih.gov/pubmed/31581475
http://dx.doi.org/10.3390/jfb10040045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963571/
https://www.ncbi.nlm.nih.gov/pubmed/31581475
http://dx.doi.org/10.3390/jfb10040045

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