Single-Domain Antibodies as Crystallization Chaperones to Enable Structure-Based Inhibitor Development for RBR E3 Ubiquitin Ligases

Protein ubiquitination plays a key role in the regulation of cellular processes, and misregulation of the ubiquitin system is linked to many diseases. So far, development of tool compounds that target enzymes of the ubiquitin system has been slow and only a few specific inhibitors are available. Her...

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Detalles Bibliográficos
Autores principales: Tsai, Yi-Chun Isabella, Johansson, Henrik, Dixon, David, Martin, Stephen, Chung, Chun-wa, Clarkson, Jane, House, David, Rittinger, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963773/
https://www.ncbi.nlm.nih.gov/pubmed/31813847
http://dx.doi.org/10.1016/j.chembiol.2019.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963773/
https://www.ncbi.nlm.nih.gov/pubmed/31813847
http://dx.doi.org/10.1016/j.chembiol.2019.11.007

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