Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline

Bedaquiline (BDQ) inhibits ATP generation in Mycobacterium tuberculosis by interfering with the F-ATP synthase activity. Two mechanisms of action of BDQ are broadly accepted. A direct mechanism involves BDQ binding to the enzyme’s c-ring to block its rotation, thus inhibiting ATP synthesis in the en...

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Detalles Bibliográficos
Autores principales: Sarathy, Jickky Palmae, Gruber, Gerhard, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963887/
https://www.ncbi.nlm.nih.gov/pubmed/31835707
http://dx.doi.org/10.3390/antibiotics8040261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963887/
https://www.ncbi.nlm.nih.gov/pubmed/31835707
http://dx.doi.org/10.3390/antibiotics8040261

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