Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in Mycobacterium tuberculosis by Competing with tmRNA

Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in M. tuberculosis. Recently, the bifunctional enzyme Rv2783 was reported as a new target of POA. However, the mechanism by which POA inhibits Rv2783 is not...

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Detalles Bibliográficos
Autores principales: He, Lei, Cui, Peng, Shi, Wanliang, Li, Qiong, Zhang, Wenhong, Li, Min, Zhang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963974/
https://www.ncbi.nlm.nih.gov/pubmed/31718097
http://dx.doi.org/10.3390/pathogens8040230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963974/
https://www.ncbi.nlm.nih.gov/pubmed/31718097
http://dx.doi.org/10.3390/pathogens8040230

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