Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation

BACKGROUND: Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bone mass homeostasis. Our group prior demonstrated that activation of CNR2 signa...

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Detalles Bibliográficos
Autores principales: Xu, Aihua, Yang, Yang, Shao, Yang, Wu, Meng, Sun, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964093/
https://www.ncbi.nlm.nih.gov/pubmed/31941496
http://dx.doi.org/10.1186/s12964-020-0512-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964093/
https://www.ncbi.nlm.nih.gov/pubmed/31941496
http://dx.doi.org/10.1186/s12964-020-0512-6

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