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Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction

Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enri...

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Detalles Bibliográficos
Autores principales: Kaczmarek, Renata, Korczyński, Dariusz, Green, James R, Dembinski, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964655/
https://www.ncbi.nlm.nih.gov/pubmed/31976010
http://dx.doi.org/10.3762/bjoc.16.1