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Understanding the role of active site residues in CotB2 catalysis using a cluster model

Terpene cyclases are responsible for the initial cyclization cascade in the multistep synthesis of a large number of terpenes. CotB2 is a diterpene cyclase from Streptomyces melanosporofaciens, which catalyzes the formation of cycloocta-9-en-7-ol, a precursor to the next-generation anti-inflammatory...

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Detalles Bibliográficos
Autores principales: Raz, Keren, Driller, Ronja, Brück, Thomas, Loll, Bernhard, Major, Dan T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964657/
https://www.ncbi.nlm.nih.gov/pubmed/31976016
http://dx.doi.org/10.3762/bjoc.16.7