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Understanding the role of active site residues in CotB2 catalysis using a cluster model
Terpene cyclases are responsible for the initial cyclization cascade in the multistep synthesis of a large number of terpenes. CotB2 is a diterpene cyclase from Streptomyces melanosporofaciens, which catalyzes the formation of cycloocta-9-en-7-ol, a precursor to the next-generation anti-inflammatory...
Autores principales: | Raz, Keren, Driller, Ronja, Brück, Thomas, Loll, Bernhard, Major, Dan T |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964657/ https://www.ncbi.nlm.nih.gov/pubmed/31976016 http://dx.doi.org/10.3762/bjoc.16.7 |
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