Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma

BACKGROUND: Oncolytic viro-immunotherapy holds promise for cancer treatment. While immune activation can be robustly triggered by oncolytic viruses, negative feedback is often upregulated in the tumour microenvironment (TME). Lactate accumulation, signal transducer and activator of transcription 3 (...

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Detalles Bibliográficos
Autores principales: Meng, Gang, Li, Binghua, Chen, Anxian, Zheng, Meihong, Xu, Tiancheng, Zhang, Hailin, Dong, Jie, Wu, Junhua, Yu, Decai, Wei, Jiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964686/
https://www.ncbi.nlm.nih.gov/pubmed/31819179
http://dx.doi.org/10.1038/s41416-019-0639-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964686/
https://www.ncbi.nlm.nih.gov/pubmed/31819179
http://dx.doi.org/10.1038/s41416-019-0639-7

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