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First eight residues of apolipoprotein A-I mediate the C-terminus control of helical bundle unfolding and its lipidation
The crystal structure of a C-terminal deletion of apolipoprotein A-I (apoA1) shows a large helical bundle structure in the amino half of the protein, from residues 8 to 115. Using site directed mutagenesis, guanidine or thermal denaturation, cell free liposome clearance, and cellular ABCA1-mediated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964839/ https://www.ncbi.nlm.nih.gov/pubmed/31945064 http://dx.doi.org/10.1371/journal.pone.0221915 |