Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae

The Ribosome-associated Quality Control (RQC) pathway co-translationally marks incomplete polypeptides from stalled translation with two signals that trigger their proteasome-mediated degradation. The E3 ligase Ltn1 adds ubiquitin and Rqc2 directs the large ribosomal subunit to append carboxy-termin...

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Detalles Bibliográficos
Autores principales: Sitron, Cole S., Park, Joseph H., Giafaglione, Jenna M., Brandman, Onn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964901/
https://www.ncbi.nlm.nih.gov/pubmed/31945107
http://dx.doi.org/10.1371/journal.pone.0227841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964901/
https://www.ncbi.nlm.nih.gov/pubmed/31945107
http://dx.doi.org/10.1371/journal.pone.0227841

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