Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease has been challenging. Here we annotate changes to gen...

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Detalles Bibliográficos
Autores principales: Castelijns, Bas, Baak, Mirna L., Timpanaro, Ilia S., Wiggers, Caroline R. M., Vermunt, Marit W., Shang, Peng, Kondova, Ivanela, Geeven, Geert, Bianchi, Valerio, de Laat, Wouter, Geijsen, Niels, Creyghton, Menno P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965079/
https://www.ncbi.nlm.nih.gov/pubmed/31949148
http://dx.doi.org/10.1038/s41467-019-14269-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965079/
https://www.ncbi.nlm.nih.gov/pubmed/31949148
http://dx.doi.org/10.1038/s41467-019-14269-w

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