A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice

We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1l(p.S78G) mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (m.G14904A, mt-Cyb(p.D254N)), affecting the CIII...

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Detalles Bibliográficos
Autores principales: Purhonen, Janne, Grigorjev, Vladislav, Ekiert, Robert, Aho, Noora, Rajendran, Jayasimman, Pietras, Rafał, Truvé, Katarina, Wikström, Mårten, Sharma, Vivek, Osyczka, Artur, Fellman, Vineta, Kallijärvi, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965120/
https://www.ncbi.nlm.nih.gov/pubmed/31949167
http://dx.doi.org/10.1038/s41467-019-14201-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965120/
https://www.ncbi.nlm.nih.gov/pubmed/31949167
http://dx.doi.org/10.1038/s41467-019-14201-2

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