Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability but their evolution has not been investigated....

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Detalles Bibliográficos
Autores principales: von Loga, Katharina, Woolston, Andrew, Punta, Marco, Barber, Louise J., Griffiths, Beatrice, Semiannikova, Maria, Spain, Georgia, Challoner, Benjamin, Fenwick, Kerry, Simon, Ronald, Marx, Andreas, Sauter, Guido, Lise, Stefano, Matthews, Nik, Gerlinger, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965135/
https://www.ncbi.nlm.nih.gov/pubmed/31949146
http://dx.doi.org/10.1038/s41467-019-13915-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965135/
https://www.ncbi.nlm.nih.gov/pubmed/31949146
http://dx.doi.org/10.1038/s41467-019-13915-7

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