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Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity

Female reproductive success critically depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals eliminate up to 80% of the initial oocyte pool through the enigmatic process of fetal oocyte attrition (FOA). Here, we interrogate the striking correlation of FOA with retrotran...

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Detalles Bibliográficos
Autores principales: Tharp, Marla E., Malki, Safia, Bortvin, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965193/
https://www.ncbi.nlm.nih.gov/pubmed/31949138
http://dx.doi.org/10.1038/s41467-019-14055-8