Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular endothelium (VE). The most principle mechanism might be excess reactive oxygen species (ROS) generation. Nevertheless, the characteristics of ROS generation, downstream mechanisms, and target organelles in Dox-induce...

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Detalles Bibliográficos
Autores principales: He, Huan, Wang, Liang, Qiao, Yang, Zhou, Qing, Li, Hongwei, Chen, Shuping, Yin, Dong, Huang, Qing, He, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965327/
https://www.ncbi.nlm.nih.gov/pubmed/31998130
http://dx.doi.org/10.3389/fphar.2019.01531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965327/
https://www.ncbi.nlm.nih.gov/pubmed/31998130
http://dx.doi.org/10.3389/fphar.2019.01531

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