Correction of the aprt Gene Using Repair-Polypurine Reverse Hoogsteen Hairpins in Mammalian Cells

In this study, we describe the correction of single-point mutations in mammalian cells by repair-polypurine reverse Hoogsteen hairpins (repair-PPRHs). These molecules consist of (1) a PPRH hairpin core that binds to a polypyrimidine target sequence in the double-stranded DNA (dsDNA), producing a tri...

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Detalles Bibliográficos
Autores principales: Félix, Alex J., Ciudad, Carlos J., Noé, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965513/
https://www.ncbi.nlm.nih.gov/pubmed/31945727
http://dx.doi.org/10.1016/j.omtn.2019.12.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965513/
https://www.ncbi.nlm.nih.gov/pubmed/31945727
http://dx.doi.org/10.1016/j.omtn.2019.12.015

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